Posts from the ‘genetics’ Category
This protein is the result of spelling out the Universal Declaration of Human Rights in amino acids (with a couple substitutions being made for non-corresponding letters).
Most scientists have long asserted that the Americas were peopled in one large migration from Siberia that happened about 15,000 years ago, but new full-genome research shows that this central episode was followed by at least two smaller migrations from Siberia, one by people who became the ancestors of today’s Eskimos and Aleutians and another by people speaking Na-Dene, whose descendants (Apache, Navajo, Chipewyan, and others) are confined to North America. The research, which confirms linguist Joseph Greenberg’s rejected 1987 hypothesis, was published online on Wednesday in the journal Nature.
Abuse Lingers in the Genes and Brain
By studying both rats and humans, a team of biologists from Montreal, Canada and Singapore has uncovered a link between abuse and neglect in early life and epigenetic changes in how the brain regulates stress. Translated literally, “epigenetic” means “on top of genetics.” Epigenetic changes do not alter the code of an individual’s DNA, but rather add a molecule to the surface of the code. Such modifications affect the way in which the DNA’s instructions are carried out in the body.
In this study, the researchers found that victims of abuse and neglect during childhood had epigenetic modifications on a stress-regulating gene that acts in the brain. The modifications left these subjects less able to quiet their body’s natural reactions to stressful situations. The finding helps clarify the physical and mental impacts of childhood trauma and could pave the way for new mental health treatments. The research was published in the journal Nature Neuroscience.
Repeat after me, it’s not your fault.
Epigenetics is a quickly expanding and key field of genetics. We’re learning how environmental factors – diet, treatment, habits – can have long-standing and generation-bridging consequences. While the DNA code itself isn’t changed, the way it is twisted and read can be, with varying results.
Geneticist Runs Personalized Medicine Superstudy On Himself
Michael Snyder has taken “know thyself” to the next level — and helped heal thyself.
Over a 14-month period, the molecular geneticist at Stanford University in Palo Alto, California, analyzed his blood 20 different times to pluck out a wide variety of biochemical data depicting the status of his body’s immune system, metabolism, and gene activity. In today’s issue of Cell, Snyder and a team of 40 other researchers present the results of this extraordinarily detailed look at his body, which they call an integrative personal omics profile (iPOP) because it combines cutting-edge scientific fields such as genomics (study of one’s DNA), metabolomics (study of metabolism), and proteomics (study of proteins). Instead of seeing a snapshot of the body taken during the typical visit to a doctor’s office, iPOP effectively offers an IMAX movie, which in Snyder’s case had the added drama of charting his response to two viral infections and the emergence of type 2 diabetes.
The work being done in the ‘omics is fascinating, and I don’t think it will be too long before this kind of testing is standard for occasional checkups, much like physicals are today. The danger is the inevitable discrimination that will result, and the remedy for that is educating our current and future policy makers and managers to avoid that mistake.